Inhalation systems | Features of available devices | DPI | Diskus® | Use of Diskus

Course of particles using a dry powder inhaler (DPI)

Diskus® The Diskus® is an inhalation device with low intrinsic resistance emitting about double the dose of fine particles at an inspiratory flow of 30 l/min compared with the Turbuhaler®. With an inspiratory flow of 60 l/min no significant difference is observed between the two devices. In-vitro formation of the fine particle fraction in the Diskus® also does not change with the inspiratory flow. Hence this device provides relatively constant intra-bronchial drug deposition independent of flow.

It also has been demonstrated that with an inspiratory flow of only 30 l/min 80% of the metered dose reached the mouthpiece. However since the prepared dosages are not completely emptied and powder is distributed all over the Diskus® after a short time of usage dose consistency appears to be uncertain.

Drugs approved for the use with the Diskus® include fluticasone (Flixotide®, Flovent®, Flutide®), salmeterol (Serevent®) and a combination of both substances (Advair®, Viani®).

Literature:

Hill LS, Slater AL. A comparison of the performance of two modern multidose dry powder asthma inhalers. 1998. Respir Med; 92: 105-110

Malton A, Sumby BS, Smith IJ. A comparison of in vitro drug delivery from two multidose powder inhalation devices. 1995. Eur J Clin Res; 7: 177-193

Thorsson L, Edsbäcker S, Källen A Löfdahl CG. Pharmacokinetics and systemic activity of fluticasone via Diskus and pMDI, and of budesonide via Turbuhaler. 2001. Clin Pharmacol; 52: 529-538

Voshaar T. Therapie mit Aerosolen. 2005. Uni-Med: Bremen <

Correct use of the Diskus®

Hold the outer casing of the inhaler in one hand whilst pushing the thumb grip away until a click is heard.
Hold the inhaler with the mouthpiece towards you and slide lever away until it clicks. This makes the dose available for inhalation and moves the dose counter on.
Holding the inhaler level, breathe out gently away from the device, put the mouthpiece in your mouth and suck in steadily and deeply.
Remove the inhaler from your mouth and hold breath for about 10 seconds.
To close, slide thumb grip back towards you as far as it will go until it clicks.

Select language

Search

Contact

Do you have questions?
Contact our experts...


Contact

Related Pages